Cerebellar Granule cell modelling

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Padraig Gleeson, 30 Apr 2014 14:57

Towards community developed cerebellar granule cell models

This project was started following the 2013 OSB kickoff meeting. At that meeting it was decided that the development of individual cell models from the cerebellum would be a good test case for exploring the requirements on technical infrastructure and the social aspects of collaborative model development. Due to the many independent granule cell layer networks being developed by participants at the OSB meeting, the cerebellar granule cell was identified as a good first cell model to focus on.

This wiki is intended to help gather the following information/requirements:

  • What granule cell models are out there?
  • What electrophysiological properties do labs wish to reproduce in their models?
  • What experimental data is publicly available on the behaviour of the granule cell?
  • How well do existing models reproduce these behaviours?

Models of the cerebellar granule cell

Models on OSB

Cerebellar Granule Cell - Maex De Schutter 1998
Cerebellar Granule Cell - Solinas et al. 2010
Granule Cell - Steuber, Saviane & Berends
I&F granule cell model - Rothman & Piasini

Other known models

Links to entries on ModelDB or PubMed articles…

Target electrophysiological properties of granule cells

To facilitate comparison between granule cell models it would be good to quantify certain properties of the cell activity which labs find in their experimental data and which should be reproduced in models. An initial list of properties is:

  • Resting Potential
  • Input Resistance
  • Reversal potential of Na
  • Reversal potential of K
  • AP max depolarisation
  • Firing rate at ?? Hz
  • Total cell capacitance
  • Soma radius
  • More…

Different species, drugs, experimental conditions will lead to different values for these between labs. Nevertheless, it would be good to get input from as many labs as possible.

D’Angelo lab

Species: …
Experimental setup summary: …
Resting potential: …

Silver lab

Publicly accessible data on granule cell behaviour

Links to electrophysiological data in public repositories

_(Wishful thinking I know…)_

NeuroElectro properties of granule cells


How well do existing models reproduce these behaviours?

Information on construction of tests for comparing model behaviour to experimental data

Much of this will be based on NeuroUnit/SciUnit and existing test scripts in neuroConstruct projects (e.g. here).