Human L5 Cortical Circuit

We used L5 Pyr neuron models fit to electrophysiology data from younger and older individuals to simulate detailed human layer 5 microcircuits. These circuits also included detailed parvalbumin+ (PV), somatostatin+ (SST), and vasoactivate intestinal polypeptide+ (VIP) inhibitory interneuron models.

Guet-McCreight A, Chameh HM, Mahallati S, Wishart M, Tripathy SJ, Valiante TA, Hay E. (2022). Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity. Cereb. Cortex. DOI:

Developer: Alexandre Guet-McCreight

Scientific Coordinator: Alexandre Guet-McCreight, Etay Hay

Scientific Advisor: Etay Hay

The original published version of this model is available on ModelDB

This model was originally developed in: LFPy & NEURON

The code for this model is hosted on GitHub: