A project which was used in Rothman et al. “Synaptic depression enables neuronal gain control” Nature 2009 to demonstrate gain control in realistic cell models. Based on cell model from Kole et al. 2008 (obtained from http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=114394).
Rothman et al 2009 used cell in neuroConstruct with original mod files (File based cell mechanisms). Channels converted to ChannelML, but full cell needs further testing in NeuroML/GENESIS/MOOSE.
Developer: Padraig Gleeson
Scientific Coordinator: Jason Rothman
The original published version of this model is available on
This model was originally developed in: NEURON
The code for this model is hosted on GitHub: https://github.com/OpenSourceBrain/RothmanEtAl_KoleEtAl_PyrCell